Chemistry 1 Life Sciences A
The order of topics presented here is essentially the order of presentation in the lecture course, although individual lecturers may make some variations from this. Some topics span more than one week.
Jump to week <1> <2> <3> <4> <5> <6> <7> <8> <9> <10> <11> <12> <13>
Week |
Topics covered |
Prologue
- admin. matters
- overview of course
Atomic Structure
- electromagnetic radiation and the nature of matter
- atomic spectrum of hydrogen
- Bohr theory of the hydrogen atom
- wave mechanics
- atomic orbitals and quantum numbers
- electrons in atoms
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The Periodic Table
- metals and non-metals
- electron configuration
- d-Block elements
- trends in the periodic table
- elements essential to sustain life
- elements known to destroy life
- elements that have therapeutic value
Chemical Bonding - ionic and covalent bonds
- Lewis structures and the octet rule
- multiple bonds and resonance structures
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The Shapes of Molecules
- VSEPR theory of organic compounds
- hybridisation of organic compounds
- electronegativity, bond polarity and dipole moments
Intermolecular forces
- dipole forces
- hydrogen bonds
- dispersion (London) forces |
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Acids and Bases
- the nature of the hydrated proton
- the Brønsted Lowry theory of acids and bases
- the dissociation of water and the pH scale
- strong, weak and polyprotic acids and strong and weak bases and salts
- relation between Ka and Kb, conjugate pairs |
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Introduction to Organic Chemistry
- definition: the chemistry of carbon compounds
- importance of carbon
- hybridisation of C, O, and N
- formal charge
- writing structural formulas, abbreviated structural formulas, use of stick notation
- functional groups
Alkanes
- nomenclature
- s-bonds and structure
- conformational and constitutional isomers
Alkenes
- nomenclature
- p-bonds and structure
- configurational isomers
- addition reactions, mechanism of electrophilic addition |
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Alkenes (continued)
- classification of nucleophiles and electrophiles
- Markovnikov's rule: carbocation stability
- reaction summary (addition reactions, orientation of addition and carbocation stability)
Aromatic Hydrocarbons
- benzene: aromaticity, resonance and molecular orbital picture
- nomenclature
- toxicity of benzene and aromatic compounds
Heterocyclic Compounds
- pyridine, pyrrole, furan, thiophene, imidazole
- purine, pyrimidine
- relevance to DNA |
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Organic Halogen Compounds
- alkyl halides: classification as 1°, 2°, 3°
- nomenclature
- nucleophilic substitution reactions of 1° and 2°
- reaction summary
Alcohols, Phenols, Ethers and Thiols
- alcohols: classification as 1°, 2°, 3°
- nomenclature
- hydrogen bonding
- acid-base reactions of alcohols and phenols
- reactions of alcohols: dehydration, oxidation, substitution
- physiological importance; alcohol poisoning
- phenols: acidity and aromatic electrophilic substitution
- thiols: acidity and oxidation to disulfides
- NADH/NAD+ cycle and thiol disulfide redox cycle
- biologically important thiols and disulfides |
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Amines
- amines: classification as 1°, 2°, 3°, 4° and aryl amines (aniline)
- nomenclature
- basicity and alkylation of 3° amines
- conversion to amides
- examples of biologically active amines
Aldehydes and Ketones
- nomenclature
- nucleophilic addition reactions, formation of hemiacetals and acetals
- oxidation and reduction and NADH/NAD+
- tautomerism
Spectroscopy
- mass spectrometry
- infrared spectroscopy
- UV-visible spectroscopy |
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Spectroscopy (continued)
- 1H NMR spectroscopy
- MRI and medical applications
Carboxylic Acids and Derivatives
- nomenclature
- acidity
- acid derivatives: acid chlorides, esters, thioesters, amides
- relative reactivities, preparation and hydrolysis
- b-keto acids and decarboxylation
- fats, waxes and oils |
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Stereochemistry
- constitutional isomers and stereoisomers (enantiomers and diastereomers)
- stereogenic centres
- optical activity
- (R), (S) nomenclature and D, L nomenclature
- racemic mixtures and resolution of enantiomers
- compounds with 2 stereogenic centres including meso isomers
- importance of chirality in nature and drug design |
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Carbohydrates
- monosaccharides: nomenclature and stereochemistry
- Haworth projections, open and closed chain forms
- reactions of monosaccharides
- reducing and non-reducing sugars, mutarotation
- disaccharides and polysaccharides: classification and hydrolysis |
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Amino Acids, Peptides and Proteins
- structure and classification of amino acids, stereochemistry
- acid base chemistry
- formation and hydrolysis of peptides
- protein structure overview |
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DNA and Nucleic Acids
- tautomerism in heterocycles
- DNA bases
- nucleosides, nucleotides, ATP, ADP, AMP
- DNA structure
Summary of Classes of Reactions
- acid-base reactions
- addition reactions: electrophilic and nucleophilic elimination
- substitution reactions: electrophilic and nucleophilic
- redox reactions: oxidation and reduction
Examples of Synthetic Transformations |
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TextbookBlackman, Bottle, Schmid, Mocerino and Wille, |